2-Amino-5-bromopyridine → 2-[(5-Bromopyridin-2-yl)amino]-2-oxoacetic acid methyl ester

HRID 2104387Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.Cl[C:10](=[O:15])[C:11]([O:13][CH3:14])=[O:12]>>[CH3:14][O:13][C:11](=[O:12])[C:10]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1)=[O:15]

Participants

Reactant 2

HCID 706222-Amino-5-bromopyridine

HCID 79846Methyl chloroglyoxylate

Product 1

HCID 574326082-[(5-Bromopyridin-2-yl)amino]-2-oxoacetic acid methyl ester

Procedure

In a manner similar to that employed in Referential Example 242, the title compound was prepared from 2-amino-5-bromopyridine and methyl chlorooxoacetate.

Sources & evidence

ORD record: ord-8342c9fd146b42efa220e36ea47535f2
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07576135B2

Reaction notes

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