2-Amino-5-chlorothiazole → Methyl 2-((5-chlorothiazol-2-yl)amino)-2-oxoacetate

HRID 2104389Notes

Reaction equation

[NH2:1][C:2]1[S:3][C:4]([Cl:7])=[CH:5][N:6]=1.Cl[C:9](=[O:14])[C:10]([O:12][CH3:13])=[O:11]>>[CH3:13][O:12][C:10](=[O:11])[C:9]([NH:1][C:2]1[S:3][C:4]([Cl:7])=[CH:5][N:6]=1)=[O:14]

Participants

Reactant 2

HCID 389422-Amino-5-chlorothiazole

HCID 79846Methyl chloroglyoxylate

Product 1

HCID 45117893Methyl 2-((5-chlorothiazol-2-yl)amino)-2-oxoacetate

Procedure

In a manner similar to that employed in Referential Example 242, the title compound was prepared from 2-amino-5-chlorothiazole and methyl chlorooxoacetate.

Sources & evidence

ORD record: ord-17bd761390964fce894524379b7b94a1
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07576135B2

Reaction notes

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