3-Chloroaniline → N-(3-Chlorophenyl)-3-ethoxy-3-oxopropanimidic acid

HRID 2104410Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].[C:9]([O:15][CH2:16][CH3:17])(=[O:14])[CH2:10][C:11]([O-])=[O:12].[K+]>>[CH2:16]([O:15][C:9](=[O:14])[CH2:10][C:11]([NH:5][C:4]1[CH:6]=[CH:7][CH:8]=[C:2]([Cl:1])[CH:3]=1)=[O:12])[CH3:17]

Participants

Reactant 2

HCID 79323-Chloroaniline

HCID 3446434Potassium ethyl malonate

Product 1

HCID 12741173N-(3-Chlorophenyl)-3-ethoxy-3-oxopropanimidic acid

Procedure

In a manner similar to that described in Referential Example 370, 3-chloroaniline was condensed with potassium ethyl malonate, whereby the title compound was obtained.

Sources & evidence

ORD record: ord-bcd55d6260fb43e3837411b319212b75
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07576135B2

Reaction notes

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