HCID 59677009, compound → HCID 67056666, compound

HRID 2104457Notes

Reaction equation

HRID 2104457 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([NH:13][C@@H:14]([C@H:21]([NH:24][C:25]([C:27]1[S:28][C:29]3[CH2:30][N:31]([CH3:36])[CH2:32][CH2:33][C:34]=3[N:35]=1)=[O:26])CO)[CH2:15][C:16]([O:18][CH2:19]C)=[O:17])=[O:12])=[CH:5]2>Cl.O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([NH:13][C@@H:14]1[CH2:15][C:16](=[O:17])[O:18][CH2:19][C@H:21]1[NH:24][C:25]([C:27]1[S:28][C:29]3[CH2:30][N:31]([CH3:36])[CH2:32][CH2:33][C:34]=3[N:35]=1)=[O:26])=[O:12])=[CH:5]2

Participants

3

Reactant 1

HCID 59677009HCID 59677009, compound

Product 1

HCID 67056666HCID 67056666, compoundYield 151.1%

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

4N HCl-dioxane (20 mL) was added to the compound (0.31 g) obtained in Example 176, and the mixture was heated under reflux for 4 hours. The reaction mixture was concentrated, and the resultant residue was recrystallized from diethyl ether to give the title compound (0.23 g).

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 4 hours
  3. concentrationThe reaction mixture was concentrated
  4. customthe resultant residue was recrystallized from diethyl ether

Sources & evidence

ORD record
ord-3ebbf279107848b0a8ed58561998921e
Source dataset
uspto-grants-2009_08
Patent number
US07576135B2

Reaction notes

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