4-tert-Butylphenylboronic acid → [4-(4-Tert-Butylphenyl)-8-(Trifluoromethyl)Quinolin-3-yl](Pyridin-2-yl)Methanone

HRID 2104482Notes

Reaction equation

HRID 2104482 reaction equation
Cl[C:2]1[C:11]2[C:6](=[C:7]([C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=1)=[O:17].[C:24]([C:28]1[CH:33]=[CH:32][C:31](B(O)O)=[CH:30][CH:29]=1)([CH3:27])([CH3:26])[CH3:25]>>[C:24]([C:28]1[CH:33]=[CH:32][C:31]([C:2]2[C:11]3[C:6](=[C:7]([C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:9][CH:10]=3)[N:5]=[CH:4][C:3]=2[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=2)=[O:17])=[CH:30][CH:29]=1)([CH3:27])([CH3:26])[CH3:25]

Participants

3

Reactant 2

HCID 27343204-tert-Butylphenylboronic acidHCID 66913162(4-Chloro-8-trifluoromethyl-quinolin-3-yl)-pyridin-2-yl-methanone

Product 1

HCID 11453296[4-(4-Tert-Butylphenyl)-8-(Trifluoromethyl)Quinolin-3-yl](Pyridin-2-yl)Methanone

Procedure

This compound was prepared using the procedure of Example 1, step 5 using (4-chloro-8-trifluoromethyl-quinolin-3-yl)-pyridin-2-yl-methanone in place of [4-chloro-8-(trifluoromethyl)quinolin-3-yl](phenyl)methanone and 4-t-butylphenylboronic acid in place of phenyl boronic acid. MS (ESI) m/z 435 ([M+H]+); Anal. Calcd for C26H21F3N2O: C, 71.88; H, 4.87; N, 6.45. Found: C, 71.51; H, 5.09; N, 6.22.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-3916a4b1548b44a2ae7bc1341ad80051
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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