Hydrochloric Acid → 3-Benzyl-4-(4-methoxyphenyl)-8-(trifluoromethyl)quinoline

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Reaction Steps

This compound was prepared using the procedure of Example 31 substituting [4-(4-methoxyphenyl)-8-(trifluoromethyl)quinolin-3-yl](phenyl)methanone of Example 2 for 2 phenyl[4-phenyl-8-(trifluoromethyl)quinolin-3-yl]methanone. The HCl salt was further prepared using HCl in ether. MS (ESI) m/z 394 ([M+H]+); 1H NMR (acetone-d6) δ 8.97 (s, 1H), 8.12 (d, J=7.2 Hz, 1H), 7.76 (d, J=8.4 Hz, 1H), 7.63 (m, 1H), 7.25 (m, 4H), 7.15 (m, 3H), 7.07 (d, J=7.5 Hz, 2H), 4.08 (s, 2H), 3.92 (s, 3H).

Provenance & Evidence