反应详情

A solution of 2-benzoyl-3-(2-trifluoromethyl-phenylamino)-acrylic acid ethyl ester(8.2 g, 22.4 mmol) in Dowtherm (120 ml) was heated to reflux. After 4 hr, the reaction was cooled and poured in hexane. The resulting solid was filtered and washed with hexane to give (4-hydroxy-8-trifluoromethyl-quinolin-3-yl)-phenyl-methanone (4.0 g, Yield=56%); MS (ESI) m/z 318(M+H)+; Anal Calcd for C17H10F3NO2: C, 63.36; H, 3.18; N, 4.41. Found: C, 63.96; H, 3.14; N, 4.25.

1. temperaturethe reaction was cooled
2. filtrationThe resulting solid was filtered
3. washwashed with hexane