Formaldehyde → (4-{[{3-[3-Benzoyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenyl}(Methyl) Amino]Methyl}Phenyl)Acetic Acid

Participants

Reaction Steps

The title compound was prepared from methyl {4-[({3-[3-benzoyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}acetate and 37% aqueous formaldehyde followed the procedures of Example 66 as an orange solid MS (EI) m/z 555.3 (M+H)+; 1H NMR (DMSO-d6): δ 2.86 (s, 3H), 3.55 (s, 2H), 4.44 (s, 2H), 6.50 (d, J=7.5 Hz, 1H), 6.60-6.65 (m, 2H), 6.98 (d, J=8.1 Hz, 2H), 7.09 (t, J=7.9 Hz, 1H), 7.18 (d, J=8.0 Hz, 2H), 7.36 (t, J=7.4 Hz, 2H), 7.55 (t, J=6.2 Hz, 1H), 7.64 (d, J=7.0 Hz, 2H), 7.73 (t, J=7.8 Hz, 1H), 8.01 (d, J=7.7 Hz, 1H), 8.30 (d, J=7.0 Hz, 1H), 9.10 (s, 1H), 12.31 (br s, 1H).

Provenance & Evidence