Acetic Acid → HCID 66914350, compound

Participants

Reaction Steps

(4-Aminophenyl)[4-phenyl-8-(trifluoromethyl)quinolin-3-yl]methanone (0.050 g, 0.127 mmol) in AcOH (2 mL) is added slowly to a stirred solution of NaBO3 4H2O (0.098 g, 0.637 mmol) in AcOH (3 mL) at 55° C. over 40 min. After 1 h, the reaction is cooled, poured into water and extracted with methylene chloride. The extracts are washed with saturated aq sodium bicarbonate, dried over MgSO4 and concentrated. The residue is purified by chromatography eluting with 10:90 ethyl acetate:hexane to afford the title compound (0.0157 g). MS (ESI) m/z 423; HRMS: calcd for C23H13F3N2O3+H, 423.09565; found (ESI, [M+H]+), 423.0943.

Provenance & Evidence