Pyridinium chloride → HCID 66913800, compound

HRID 2104594Notes

Reaction equation

HRID 2104594 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]([C:11]1[CH:12]=[N:13][C:14]2[C:19]([C:20]=1[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[CH:18][CH:17]=[CH:16][C:15]=2[C:27]([F:30])([F:29])[F:28])=[O:10].Cl.N1C=CC=CC=1>>[OH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]([C:11]1[CH:12]=[N:13][C:14]2[C:19]([C:20]=1[C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)=[CH:18][CH:17]=[CH:16][C:15]=2[C:27]([F:30])([F:28])[F:29])=[O:10]

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 11165687HCID 11165687, compound

Product 1

HCID 66913800HCID 66913800, compoundYield 81.4%

Procedure

(2-Methoxyphenyl)[4-phenyl-8-(trifluoromethyl)quinolin-3-yl]methanone (0.853 g, 2.09 mmol) and pyridine hydrochloride are heated at 200° C. for 4 h. The reaction is worked up and purified as in Example above except eluting with 10:90 ethyl acetate:hexane to afford the title product as white solid (0.669 g, 81%). MS (ESI) m/z 392.0901; HRMS: calcd for C23H14F3NO2—H, 392.08984; found (ESI, [M−H]−), 392.0901.

Workup

  1. washexcept eluting with 10:90 ethyl acetate

Sources & evidence

ORD record
ord-5bb1215c602d4bef91c63d01257a783b
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

Loading…