HCID 66913459, compound → HCID 23648468, compound

HRID 2104609Notes

Reaction equation

HRID 2104609 reaction equation
[C:1]1([C:7]2[CH:8]=[N:9][C:10]3[C:15]([C:16]=2[C:17]2[CH:18]=[C:19]([NH:23][CH2:24][C:25]4[CH:30]=[CH:29][C:28]([CH2:31][C:32]([O:34]CC)=[O:33])=[CH:27][CH:26]=4)[CH:20]=[CH:21][CH:22]=2)=[CH:14][CH:13]=[CH:12][C:11]=3[C:37]([F:40])([F:39])[F:38])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(OC(=O)CC1C=CC=C(C2C3C(=C(C(F)(F)F)C=CC=3)N=CC=2C2C=CC=CC=2)C=1)C>>[C:1]1([C:7]2[CH:8]=[N:9][C:10]3[C:15]([C:16]=2[C:17]2[CH:18]=[C:19]([NH:23][CH2:24][C:25]4[CH:30]=[CH:29][C:28]([CH2:31][C:32]([OH:34])=[O:33])=[CH:27][CH:26]=4)[CH:20]=[CH:21][CH:22]=2)=[CH:14][CH:13]=[CH:12][C:11]=3[C:37]([F:40])([F:38])[F:39])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 66913459HCID 66913459, compoundHCID 86598755HCID 86598755, compound

Product 1

HCID 23648468HCID 23648468, compound

Procedure

The title compound is prepared essentially as described in Example 398, except using ethyl {4-[({3-[3-phenyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amino)methyl]phenyl}acetate instead 3-[3-phenyl-8-(trifluoromethyl)quinolin-4-yl]phenyl acetic acid ethyl ester to afford the title compound as a tan tacky solid (0.021 g, 31%). Calcd mass for C31H23N2F3O2 is 512.53, found MS (ES) m/z 513.

Workup

  1. customThe title compound is prepared essentially

Sources & evidence

ORD record
ord-e3e79201fe064314b480f85549141682
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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