(3-Fluorophenyl)acetaldehyde → 3-[3-(3-Fluorophenyl)-8-(trifluoromethyl)quinolin-4-yl]phenol

HRID 2104616Notes

Reaction equation

HRID 2104616 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([OH:20])[CH:15]=1)=O.[F:21][C:22]1[CH:23]=[C:24]([CH2:28][CH:29]=O)[CH:25]=[CH:26][CH:27]=1>>[F:21][C:22]1[CH:23]=[C:24]([C:28]2[CH:29]=[N:1][C:2]3[C:3]([C:12]=2[C:14]2[CH:15]=[C:16]([OH:20])[CH:17]=[CH:18][CH:19]=2)=[CH:4][CH:5]=[CH:6][C:7]=3[C:8]([F:11])([F:10])[F:9])[CH:25]=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 15811999(3-Fluorophenyl)acetaldehydeHCID 66586253[2-Amino-3-(trifluoromethyl)phenyl](3-hydroxyphenyl)methanone

Product 1

HCID 669136313-[3-(3-Fluorophenyl)-8-(trifluoromethyl)quinolin-4-yl]phenol

Procedure

The title compound was prepared from [2-amino-3-(trifluoromethyl)phenyl]-(3-hydroxy-phenyl)methanone and (3-Fluoro-phenyl)-acetaldehyde following the procedure of Example 457: MS (ESI) m/z 384; HRMS: calcd for C22H13F4NO+H+, 384.10060; found (ESI, [M+H]+), 384.0992;

Sources & evidence

ORD record
ord-7ad89374e92048e1847000d12597b8bc
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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