Propanal → 3-[3-Methyl-8-(trifluoromethyl)quinolin-4-yl]phenol

HRID 2104633Notes

Reaction equation

HRID 2104633 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([OH:20])[CH:15]=1)=O.[CH:21](=O)[CH2:22][CH3:23]>>[CH3:23][C:22]1[CH:21]=[N:1][C:2]2[C:3]([C:12]=1[C:14]1[CH:15]=[C:16]([OH:20])[CH:17]=[CH:18][CH:19]=1)=[CH:4][CH:5]=[CH:6][C:7]=2[C:8]([F:11])([F:10])[F:9]

Participants

3

Reactant 2

HCID 527PropanalHCID 66586253[2-Amino-3-(trifluoromethyl)phenyl](3-hydroxyphenyl)methanone

Product 1

HCID 665862653-[3-Methyl-8-(trifluoromethyl)quinolin-4-yl]phenol

Procedure

The title compound was prepared from [2-amino-3-(trifluoromethyl)phenyl]-(3-hydroxy-phenyl)methanone and Propionaldehyde following the procedure of Example 457: MS (ES) m/z 304.28.

Sources & evidence

ORD record
ord-c0af89f7b7e44b798e54ec5eef61254c
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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