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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2104657Generated: October 29, 2026

5-(Bromomethyl)-2-chloropyridine → [4-{3-[(6-Chloropyridin-3-yl)Methoxy]Phenyl}-8-(Trifluoromethyl)Quinolin-3-yl](Phenyl)Methanone

https://huagongshe.com/reaction/2104657

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(Bromomethyl)-2-chloropyridineHCID 6424661—
Reactant[4-(3-Hydroxyphenyl)-8-(Trifluoromethyl)Quinolin-3-yl](Phenyl)MethanoneHCID 11773771—
Product[4-{3-[(6-Chloropyridin-3-yl)Methoxy]Phenyl}-8-(Trifluoromethyl)Quinolin-3-yl](Phenyl)MethanoneHCID 86598760—

Reaction Steps

The title compound was prepared from [4-(3-hydroxyphenyl)-8-(trifluoromethyl)quinolin-3-yl](phenyl)methanone and 5-Bromomethyl-2-chloropyridine following the procedure of Example 478: MS (ES) m/z 519.1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07576215B2
Source datasetuspto-grants-2009_08
ORD IDord-c451ca961bde470b9b0f8ba67fb5b714
Source noteuspto-grants-2009_08