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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2104662Generated: October 31, 2026

[4-(3-Hydroxyphenyl)-8-(Trifluoromethyl)Quinolin-3-yl](Phenyl)Methanone → [4-{3-[(2,6-Dimethylbenzyl)Oxy]Phenyl}-8-(Trifluoromethyl)Quinolin-3-yl](Phenyl)Methanone

https://huagongshe.com/reaction/2104662

Reaction equation

Participants

RoleNameHCIDCharge
Reactant[4-(3-Hydroxyphenyl)-8-(Trifluoromethyl)Quinolin-3-yl](Phenyl)MethanoneHCID 11773771—
Reactant2-(Bromomethyl)-1,3-dimethylbenzeneHCID 13929124—
Product[4-{3-[(2,6-Dimethylbenzyl)Oxy]Phenyl}-8-(Trifluoromethyl)Quinolin-3-yl](Phenyl)MethanoneHCID 66913513—

Reaction Steps

The title compound was prepared from [4-(3-hydroxyphenyl)-8-(trifluoromethyl)quinolin-3-yl](phenyl)methanone and 2-Bromomethyl-1,3-dimethylbenzene following the procedure of Example 478: MS (ES) m/z 511.5.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07576215B2
Source datasetuspto-grants-2009_08
ORD IDord-08ee622c65c2403dab059a0596d7f436
Source noteuspto-grants-2009_08