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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2104713Generated: October 25, 2026

2-(Bromomethyl)-4-chloro-1-(trifluoromethyl)benzene → 3-Benzyl-4-(3-{[5-Chloro-2-(Trifluoromethyl)Benzyl]Oxy}Phenyl)-8-(Trifluoromethyl)Quinoline

https://huagongshe.com/reaction/2104713

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Bromomethyl)-4-chloro-1-(trifluoromethyl)benzeneHCID 2778116—
Reactant3-[3-Benzyl-8-(trifluoromethyl)quinolin-4-yl]phenolHCID 53630755—
Product3-Benzyl-4-(3-{[5-Chloro-2-(Trifluoromethyl)Benzyl]Oxy}Phenyl)-8-(Trifluoromethyl)QuinolineHCID 86598766—

Reaction Steps

The title compound was prepared from 3-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl]phenol and 5-chloro-2-trifluoromethylbenzyl bromide as in the procedure of Example 43. MS (ESI) m/z 572.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07576215B2
Source datasetuspto-grants-2009_08
ORD IDord-314dcdfb6fd240f4890a3b916c25ff24
Source noteuspto-grants-2009_08