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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2104717Generated: October 25, 2026

Phenol → 5-({3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Benzyl}Oxy)-1H-Indole-2-Carboxylic Acid

https://huagongshe.com/reaction/2104717

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhenolHCID 996—
Reactant{3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenyl}MethanolHCID 11223110—
Reactantmethyl 5-hydroxy-1H-indole-2-carboxylateHCID 21904362—
Product5-({3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Benzyl}Oxy)-1H-Indole-2-Carboxylic AcidHCID 66913706—

Reaction Steps

The title compound was prepared using the procedure of example 69 using 5-Hydroxy-1H-indole-2-carboxylic acid methyl ester as the phenol and [3-(3-Benzyl-8-trifluoromethyl-quinolin-4-yl)-phenyl]-methanol as the alcohol. MS (ESI) m/z 553.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07576215B2
Source datasetuspto-grants-2009_08
ORD IDord-8b6f5f3c049e44218f604c6e0f2fb9b3
Source noteuspto-grants-2009_08