2-Fluorophenyl isocyanate → HCID 66913689, compound

HRID 2104720Notes

Reaction equation

HRID 2104720 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:19]=[C:20]([NH2:24])[CH:21]=[CH:22][CH:23]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[C:25]([F:28])([F:27])[F:26].[F:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=1[N:36]=[C:37]=[O:38]>>[F:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=1[NH:36][C:37]([NH:24][C:20]1[CH:21]=[CH:22][CH:23]=[C:18]([C:17]2[C:16]3[C:11](=[C:12]([C:25]([F:26])([F:28])[F:27])[CH:13]=[CH:14][CH:15]=3)[N:10]=[CH:9][C:8]=2[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[CH3:1])[CH:19]=1)=[O:38]

Participants

3

Reactant 2

HCID 855882-Fluorophenyl isocyanateHCID 66913650HCID 66913650, compound

Product 1

HCID 66913689HCID 66913689, compound

Procedure

The title compound was prepared from {3-[3-(2-methylphenyl)-8 (trifluoromethyl)quinolin-4-yl]phenyl}amine and 2-fluorophenyl isocyanate in substantially the same manner as described in Example 65; off-white solid: mp 218-220° C.; MS (EI) m/z 516 (M+H)+.

Sources & evidence

ORD record
ord-549f8d39995144008a1ded938989df51
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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