Sodium Hydroxide → HCID 66913886, compound

HRID 2104722Notes

Reaction equation

HRID 2104722 reaction equation
[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:19]=[C:20]([NH2:24])[CH:21]=[CH:22][CH:23]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[C:25]([F:28])([F:27])[F:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([O:31][C:32]([CH2:34][CH2:35][C:36]1[CH:41]=[CH:40][C:39](B(O)O)=[CH:38][CH:37]=1)=[O:33])C.[OH-].[Na+]>>[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:19]=[C:20]([NH:24][C:39]3[CH:40]=[CH:41][C:36]([CH2:35][CH2:34][C:32]([OH:33])=[O:31])=[CH:37][CH:38]=3)[CH:21]=[CH:22][CH:23]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[C:25]([F:28])([F:26])[F:27])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 38517004-(2-Ethoxycarbonylethyl)benzeneboronic acidHCID 112342973-(3-Benzyl-8-trifluoromethyl-quinolin-4-yl)-phenylamine

Product 1

HCID 66913886HCID 66913886, compound

Procedure

The title compound was prepared from {3-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amine and [4(2-ethoxycarbonylethyl)phenyl]boronic acid using the procedure of example 110 followed by hydrolysis with NaOH; MS (ESI) m/z 527([M+H]+).

Sources & evidence

ORD record
ord-9f74d8013caa47d1b73d78a916d423f1
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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