2-Fluorophenyl isocyanate → 4-[3-(2-Fluoro-phenyl)-ureidomethyl]phenylboronic acid

HRID 2104726Notes

Reaction equation

HRID 2104726 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]=[C:9]=[O:10].Cl.[NH2:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([B:20]([OH:22])[OH:21])=[CH:16][CH:15]=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:10])[NH:12][CH2:13][C:14]1[CH:15]=[CH:16][C:17]([B:20]([OH:22])[OH:21])=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 855882-Fluorophenyl isocyanateHCID 27343114-Aminomethylphenylboronic acid hydrochloride

Product 1

HCID 669137714-[3-(2-Fluoro-phenyl)-ureidomethyl]phenylboronic acid

Procedure

4-[3-(2-Fluoro-phenyl)-ureidomethyl]-phenylboronic acid was prepared from 2-fluorophenyl isocyanate and 4-aminomethylphenylboronic acid HCL salt according to the procedure of Example 65.

Sources & evidence

ORD record
ord-9ab3254cbe954bef9abbefa8e532bb09
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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