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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2104737Generated: October 26, 2026

Ethyl 4-chloro-8-(trifluoromethyl)quinoline-3-carboxylate → Ethyl 4-(3-hydroxyphenyl)-8-(trifluoromethyl)quinoline-3-carboxylate

https://huagongshe.com/reaction/2104737

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 4-chloro-8-(trifluoromethyl)quinoline-3-carboxylateHCID 725465—
Reactant(3-hydroxyphenyl)boronic AcidHCID 2734359—
ProductEthyl 4-(3-hydroxyphenyl)-8-(trifluoromethyl)quinoline-3-carboxylateHCID 66913698—

Reaction Steps

The title compound was prepared from 4-chloro-8-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester and 3-hydroxyphenylboronic acid according to the procedure of Example 1. MS (ES) m/z 359.9.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07576215B2
Source datasetuspto-grants-2009_08
ORD IDord-c448c104d4414487bba59b939e490ab9
Source noteuspto-grants-2009_08