2-Hydroxy-5-methoxybenzaldehyde → 2-[({3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenyl}Amino)Methyl]-4-Methoxyphenol

HRID 2104755Notes

Reaction equation

HRID 2104755 reaction equation
[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:19]=[C:20]([NH2:24])[CH:21]=[CH:22][CH:23]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[C:25]([F:28])([F:27])[F:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:29][C:30]1[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[CH:34][C:31]=1[CH:32]=O>>[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:19]=[C:20]([NH:24][CH2:32][C:31]3[CH:34]=[C:35]([O:38][CH3:39])[CH:36]=[CH:37][C:30]=3[OH:29])[CH:21]=[CH:22][CH:23]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[C:25]([F:28])([F:26])[F:27])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 956952-Hydroxy-5-methoxybenzaldehydeHCID 112342973-(3-Benzyl-8-trifluoromethyl-quinolin-4-yl)-phenylamine

Product 1

HCID 669137122-[({3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenyl}Amino)Methyl]-4-Methoxyphenol

Procedure

The title compound was prepared from {3-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amine and 2-hydroxy-5-methoxy-benzaldehyde according to the procedure of Example 66. MS (ES) m/z 513.0.

Sources & evidence

ORD record
ord-28e0d457c40c4050a86bbbe2f5f27b73
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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