3-(3-Benzyl-8-trifluoromethyl-quinolin-4-yl)-phenylamine → {3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenyl}[5-Chloro-2-(Trifluoromethyl)Benzyl]Amine

HRID 2104772Notes

Reaction equation

HRID 2104772 reaction equation
[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:19]=[C:20]([NH2:24])[CH:21]=[CH:22][CH:23]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[C:25]([F:28])([F:27])[F:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:29][C:30]1[CH:31]=[CH:32][C:33]([C:38]([F:41])([F:40])[F:39])=[C:34]([CH:37]=1)[CH:35]=O>>[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:19]=[C:20]([NH:24][CH2:35][C:34]3[CH:37]=[C:30]([Cl:29])[CH:31]=[CH:32][C:33]=3[C:38]([F:40])([F:39])[F:41])[CH:21]=[CH:22][CH:23]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[C:25]([F:28])([F:26])[F:27])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 112342973-(3-Benzyl-8-trifluoromethyl-quinolin-4-yl)-phenylamineHCID 177507585-Chloro-2-(trifluoromethyl)benzaldehyde

Product 1

HCID 86598775{3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenyl}[5-Chloro-2-(Trifluoromethyl)Benzyl]Amine

Procedure

The title compound was prepared from {3-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}amine and 5-chloro-2-trifluoromethyl-benzaldehyde according to the procedure of Example 66. MS (ESI) m/z 571.

Sources & evidence

ORD record
ord-8d663be8f3744c36a420db2632183be8
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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