2-Chloro-3-(trifluoromethyl)phenol → 3-Benzyl-4-(3-{[2-Chloro-3-(Trifluoromethyl)Phenoxy]Methyl}Phenyl)-8-(Trifluoromethyl)Quinoline

HRID 2104777Notes

Reaction equation

HRID 2104777 reaction equation
[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:19]=[C:20]([CH2:24][OH:25])[CH:21]=[CH:22][CH:23]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[C:26]([F:29])([F:28])[F:27])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:30][C:31]1[C:36]([C:37]([F:40])([F:39])[F:38])=[CH:35][CH:34]=[CH:33][C:32]=1O>>[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH2:24][O:25][C:32]3[CH:33]=[CH:34][CH:35]=[C:36]([C:37]([F:40])([F:39])[F:38])[C:31]=3[Cl:30])[CH:19]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[C:26]([F:29])([F:27])[F:28])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27366012-Chloro-3-(trifluoromethyl)phenolHCID 11223110{3-[3-Benzyl-8-(Trifluoromethyl)Quinolin-4-yl]Phenyl}Methanol

Product 1

HCID 865987783-Benzyl-4-(3-{[2-Chloro-3-(Trifluoromethyl)Phenoxy]Methyl}Phenyl)-8-(Trifluoromethyl)Quinoline

Procedure

The title compound was prepared from {3-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl]phenyl}methanol and 2-chloro-3-trifluoromethylphenol according to the procedure of Example 69. MS (ESI) m/z 572.

Sources & evidence

ORD record
ord-d94293aaf63647629ea254841fa6b246
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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