1-Methyl-1H-pyrrole-2-methanol → 3-Benzyl-4-{3-[(1-Methyl-1H-Pyrrol-2-yl)Methoxy]Phenyl}-8-(Trifluoromethyl)Quinoline

HRID 2104778Notes

Reaction equation

HRID 2104778 reaction equation
[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:19]=[C:20]([OH:24])[CH:21]=[CH:22][CH:23]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[C:25]([F:28])([F:27])[F:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:29][N:30]1[CH:34]=[CH:33][CH:32]=[C:31]1[CH2:35]O>>[CH2:1]([C:8]1[CH:9]=[N:10][C:11]2[C:16]([C:17]=1[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH2:35][C:31]3[N:30]([CH3:29])[CH:34]=[CH:33][CH:32]=3)[CH:19]=1)=[CH:15][CH:14]=[CH:13][C:12]=2[C:25]([F:28])([F:26])[F:27])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 1485571-Methyl-1H-pyrrole-2-methanolHCID 536307553-[3-Benzyl-8-(trifluoromethyl)quinolin-4-yl]phenol

Product 1

HCID 669140403-Benzyl-4-{3-[(1-Methyl-1H-Pyrrol-2-yl)Methoxy]Phenyl}-8-(Trifluoromethyl)Quinoline

Procedure

The title compound was prepared from 3-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl]phenol and (1-methyl-1H-pyrrol-2-yl)-methanol according to the procedure of Example 69. MS (ESI) m/z 473.

Sources & evidence

ORD record
ord-bfc1bfbd72fb469b81ae1dbd90434613
Source dataset
uspto-grants-2009_08
Patent number
US07576215B2

Reaction notes

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