1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 66914349, compound

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Reaction Steps

To 4-{[3-(3-benzyl-8-trifluoromethyl-quinolin-4-yl)-phenylamino]-methyl}-benzoic acid (130 mg, 0.254 nmol), glycine methyl ester (35 mg, 0.279 mmol) morpholine (102 mg, 1.014 mmol), EDCI (58 mg, 0.304 mmol), and HOBT (41 mg, 0.304 mmol) in CH2Cl2 (15 ml) were combined at room temperature under a nitrogen atmosphere. The resulting mixture was stirred at room temperature under a nitrogen atmosphere for 15 hrs. Quenching with brine (15 ml), separation, drying MgSO4 of the organics and concentration in vacuo. RP-HPLC (gradient water:acetonitrile) afforded the ester as an off white powder (88 mg, 61% Yield). MS (ESI) m/z 582.

Provenance & Evidence