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HRID2104914

反应详情

EQUATION

反应方程式

HRID 2104914 的结构方程式

REACTANTS

反应物

4
结构：CC(=O)O
HCID176

Acetic Acid

C2H4O2

结构：C[Si](C)(C)C(C(N)=O)[Si](C)(C)C
HCID11708267

Bistrimethylsilylacetamid

C8H21NOSi2

结构：CCCC[NH+](CCCC)CCCC.O.O.O.[F-]
HCID22252057

未命名化合物

结构：CC(C)(C)[Si](C)(C)OC(CCC(C(=O)N1C(=O)OCC1c1ccccc1)C(Nc1ccc(F)cc1)c1ccc(Br)cc1)c1ccc(F)cc1
HCID22252067

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)[Si](C)(C)OC(CCC1C(=O)N(c2ccc(F)cc2)C1c1ccc(Br)cc1)c1ccc(F)cc1
HCID22252077

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：COC(C)(C)C
溶剂HCID15413

Methyl tert-butyl ether

C5H12O

PROCEDURE

实验过程

3.34 g of 3-[2-[(4-bromophenyl)-(4-fluorophenylamino)methyl]-5-(tert-butyl-dimethylsilanyloxy)-5-(4-fluorophenyl)pentanoyl]-4-phenyloxazolidin-2-one are suspended in 70 ml of tert-butyl methyl ether. 3.8 ml of bis(trimethylsilyl)acetamide and 144 mg of tributylammonium fluoride trihydrate are then added. The reaction mixture is stirred at room temperature overnight, and 0.7 ml of glacial acetic acid are then added. The reaction mixture is concentrated using a rotary evaporator and the residue is purified by column chromatography (SiO2; ethyl acetate/heptane 1:4). The product is, obtained as a clear oil. C30H34BrF2NO2Si (586) MS (ESI): M+-131

WORKUP

后处理

  1. concentrationThe reaction mixture is concentrated
  2. customa rotary evaporator
  3. customthe residue is purified by column chromatography (SiO2; ethyl acetate/heptane 1:4)
  4. customobtained as a clear oil