Hydrochloric Acid → HCID 22252108, compound

Participants

Reaction Steps

548 mg of [5-(4-{1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-(isopropyldimethyl-silanyloxy)propyl]-4-oxoazetidin-2-yl}phenoxy)pentyl]trimethylammonium bromide are dissolved in 20 ml of methanol. 1 ml of a 0.1 M aqueous HCl solution is then added, and the reaction solution is stirred at room temperature overnight. The mixture is neutralized with dilute aqueous sodium bicarbonate solution and concentrated using a rotary evaporator. The residue is purified using a 10 g SiO2 cartridge (dichloromethane/methanol 5:1). The product is obtained as a hygroscopic solid. C32H39BrF2N2O3 (617) MS (ESI): M+-80

Provenance & Evidence