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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2104976Generated: October 30, 2026

2-Bromo-8-chloroquinoline → 4-((8-Chloroquinolin-2-yl)(5-ethoxy-2-fluoro-3-isopropoxyphenyl)methylamino)benzonitrile

https://huagongshe.com/reaction/2104976

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromo-8-chloroquinolineHCID 53217392—
Reactant4-((6-Chloroquinolin-2-yl)(5-ethoxy-2-fluoro-3-isopropoxyphenyl)methylamino)benzonitrileHCID 68816823—
Product4-((8-Chloroquinolin-2-yl)(5-ethoxy-2-fluoro-3-isopropoxyphenyl)methylamino)benzonitrileHCID 68812918—

Reaction Steps

According to the procedure for Intermediate 90.2, Intermediate 91.1 (100 mg, 0.412 mmol) afforded 165 mg of Intermediate 91.2 as an off-white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07576098B2
Source datasetuspto-grants-2009_08
ORD IDord-1f9e74c283ab4bbaaf3c65e5793aed7e
Source noteuspto-grants-2009_08