Triphenylphosphine → HCID 68813628, compound

Participants

Reaction Conditions

Reaction Steps

To triphenylphosphine (117 mg, 0.447 mmol) in THF (2 mL) at 0° C., was added diethylazodicarboxylate (71 μL, 0.447 mmol). The mixture was stirred at 0° C. for 30 min, then a solution of Intermediate 113.3 (100 mg, 0.149 mmol) and 4-hydroxy-1-methylpiperidine (34 mg, 0.298 mmol) in 1 mL THF. The mixture was allowed to warm to rt and stir 15 h, then was concentrated. The crude mixture was purified by flash chromatography (0 to 10% MeOH/CH2Cl2, gradient) to afford 77 mg of Intermediate 113.4.

Provenance & Evidence