Ethylamine hydrochloride → HCID 68813869, compound

Participants

Reaction Steps

A mixture of Intermediate 133.1 (crude, ˜30 mg), NH2Et.HCl (7 mg, 0.13 mmol), HOAt (41 mg, 0.3 mmol), EDCI (58 mg, 0.3 mmol), NaHCO3 (50 mg, 0.6 mmol) in 4:1 CH2Cl2/DMF (2 mL) was stirred at rt for 2 h. The reaction mixture was then partitioned between EtOAc and sat. NaHCO3, the organic layer was then washed by NH4Cl, and sat. NaCl, the organic layer was collected and dried over (Na2SO4), filtered and concentrated to afford Intermediate 133.2. The crude material was used without further purification in the following step.

Provenance & Evidence