Dichloromethane → HCID 68814957, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of the chloro intermediate (0.382 mmol) in 3 mL CH3CN at rt, was added DIEA (0.133 mL, 0.764 mmol), 4-aminobenzonitrile (67.7 mg, 0.573 mmol) and 1 mL CH2Cl2. The mixture was stirred at 50° C. for 3 h, then was diluted with EtOAc. The organic phase was washed with H2O and brine, dried (Na2SO4) and concentrated. The crude product was purified by flash chromatography (O to 50% EtOAc/hexanes gradient) to afford 225 mg of Intermediate 175.3 as a colorless oil. LCMS (4 min gradient, 50 to 100% B, A=95% H2O/5% CH3CN/0.1% TFA, B=95% CH3CN/5% H2O/0.1% TFA) RT=5.20 min, 623.13 (M+H)+.

Provenance & Evidence