Imidazole → tert-Butyl(5-ethyl-2-fluorophenoxy)dimethylsilane

Participants

Reaction Steps

To a solution of Intermediate 188.1 (5.42 g, 38.7 mmol) in 25 mL DMF at rt, were added imidazole (2.90 g, 42.5 mmol) and TBS-Cl (5.83 mmol). The mixture was stirred for 1.5 h, then was diluted with hexanes. The organic phase was washed with H2O (3×) and brine, dried (Na2SO4), then concentrated. Purification by flash chromatography (100% hexanes) afforded 7.50 g of Intermediate 188.2 as a colorless oil.

Provenance & Evidence