HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-1-trityl-1H-imidazole → 4-((4-bromo-1-trityl-1H-imidazol-2-yl)(3-(tert-butyldimethylsilyloxy)-5-ethyl-2-fluorophenyl)methylamino)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-1-trityl-1H-imidazole | HCID 2773274 | — |
| Reactant | 4-((4-bromo-1-trityl-1H-imidazol-2-yl)(5-ethoxy-2-fluoro-3-isopropoxyphenyl)methylamino)benzonitrile | HCID 68812817 | — |
| Reactant | HCID 178436565 | HCID 178436565 | — |
| Product | 4-((4-bromo-1-trityl-1H-imidazol-2-yl)(3-(tert-butyldimethylsilyloxy)-5-ethyl-2-fluorophenyl)methylamino)benzonitrile | HCID 68813056 | 65.6% |
Reaction Steps
According to the procedure for the preparation of Intermediate 28.1, reaction of 4-bromo-1-triphenylmethyl-imidazole (100 mg) with Intermediate 188.4 (102 mg) afforded 130 mg of Intermediate 188.5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07576098B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-e5a626b1bcc54fd486ecf5b5a74f89ae |
| Source note | uspto-grants-2009_08 |