Methyl iodide → HCID 178436893, compound

Participants

Reaction Steps

To a solution of Intermediate 206.2 (394 mg, 0.707 mmol) in 5 mL DMF at rt, were added K2CO3 (117 mg, 0.848 mmol) and iodomethane (132 μL, 2.12 mmol). The mixture was stirred at rt for 3 days, then diluted with EtOAc. The organic phase was washed with H2O (2×), sat. Na2SO3, H2O and brine, dried (Na2SO4) and concentrated. The crude product was purified by flash chromatography (0 to 60% EtOAc/hexanes gradient) to afford 359.4 mg of Intermediate 206.3 as a colorless solid.

Provenance & Evidence