HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylsilane → 2-Bromo-4-ethyl-1-fluorobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylsilane | HCID 12052 | — |
| Reactant | 1-(3-Bromo-4-fluorophenyl)ethan-1-one | HCID 70508 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 2-Bromo-4-ethyl-1-fluorobenzene | HCID 18711874 | 68.1% |
Reaction Steps
To a solution of 3′-bromo-4′-fluoroacetophenone (6.80 g, 31.3 mmol) in 31 mL TFA, was added triethylsilane (15 mL). The mixture was stirred at rt for 20 h, then concentrated. The crude product was purified by flash chromatography (100% hexanes, 2×) to afford 4.33 g of Intermediate 228.1 as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07576098B2 |
| Source dataset | uspto-grants-2009_08 |
| ORD ID | ord-6c8064900fea4c94b9bce494d35a99e2 |
| Source note | uspto-grants-2009_08 |