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HRID2105035

反应详情

EQUATION

反应方程式

HRID 2105035 的结构方程式

REACTANTS

反应物

3
结构：OB(O)c1cn[nH]c1
HCID17750278

1H-Pyrazol-4-ylboronic acid

C3H5BN2O2

结构：CCOc1cc(OC(C)C)c(F)c(C(Nc2ccc(-c3noc(C)n3)cc2)c2nc(-c3ccccc3C(F)(F)F)cn2C(c2ccccc2)(c2ccccc2)c2ccccc2)c1
HCID68813045

未命名化合物

结构：CCOc1cc(OC(C)C)c(F)c(C(Nc2ccc(-c3noc(C)n3)cc2)c2nc(Br)cn2C(c2ccccc2)(c2ccccc2)c2ccccc2)c1
HCID68813809

未命名化合物

PRODUCTS

生成物

1
结构：CCOc1cc(OC(C)C)c(F)c(C(Nc2ccc(-c3noc(C)n3)cc2)c2nc(-c3cn[nH]c3)cn2C(c2ccccc2)(c2ccccc2)c2ccccc2)c1
HCID68815685

未命名化合物

收率 20%

PROCEDURE

实验过程

According to the procedure for the preparation of Intermediate 77.1, Intermediate 66.3 was coupled with 1H-pyrazol-4-ylboronic acid. The crude product was purified by flash chromatography (0 to 100% EtOAc/hexanes, gradient) to afford 30 mg (20%) of Intermediate 237.1.

WORKUP

后处理

  1. customThe crude product was purified by flash chromatography (0 to 100% EtOAc/hexanes, gradient)