Triethylamine → tert-butyl 4-((3-ethylphenyl)(2-methyl-5-phenyl-2H-1,2,4-triazol-3-yl)methylamino)benzylcarbamate

Participants

Role	Name	HCID	Charge
Reactant	Triethylamine	HCID 8471	—
Reactant	tert-butyl N-[(4-aminophenyl)methyl]carbamate	HCID 2756041	—
Reactant	5-(chloro(3-ethylphenyl)methyl)-1-methyl-3-phenyl-1H-1,2,4-triazole	HCID 57803903	—
Solvent	Acetonitrile	HCID 6342	—
Product	tert-butyl 4-((3-ethylphenyl)(2-methyl-5-phenyl-2H-1,2,4-triazol-3-yl)methylamino)benzylcarbamate	HCID 68816261	—

Reaction Conditions

Temperature	80 °C

Reaction Steps

tert-Butyl 4-aminobenzylcarbamate (31 mg, 0.14 mmol) was added to a solution of intermediate 370.3 (43 mg,) and Et3N (0.1 mL) in acetonitrile (1 mL) and stirred at 80° C. for 16 h. The mixture was concentrated and purified by flash chromatography (EtOAc/hexanes) to yield 43 mg of intermediate 372.1 as a white solid. LCMS 498.38 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07576098B2
Source dataset	uspto-grants-2009_08
ORD ID	ord-52e70df9774745a697c36ae6583ebcdb
Source note	uspto-grants-2009_08