4-Amino-2-fluorobenzonitrile → HCID 68814212, compound

HRID 2105056Notes

Reaction equation

HRID 2105056 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([N:9]([CH2:18][C:19]2[N:20]([CH3:30])[N:21]=[C:22]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[N:23]=2)[C:10]2[CH:17]=[CH:16][C:13]([C:14]#[N:15])=[CH:12][CH:11]=2)[CH:6]=[CH:7][CH:8]=1)[CH3:2].NC1C=CC(C#N)=C([F:40])C=1>>[CH2:1]([C:3]1[CH:4]=[C:5]([N:9]([CH2:18][C:19]2[N:20]([CH3:30])[N:21]=[C:22]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[N:23]=2)[C:10]2[CH:17]=[CH:16][C:13]([C:14]#[N:15])=[C:12]([F:40])[CH:11]=2)[CH:6]=[CH:7][CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 27834134-Amino-2-fluorobenzonitrileHCID 68813790HCID 68813790, compound

Product 1

HCID 68814212HCID 68814212, compound

Procedure

According to the procedure for the preparation of Intermediate 370.4, 4-amino-2-fluorobenzonitrile (46 mg, 0.34 mmol) gave 75 mg of Intermediate 373.1 as a white solid. LCMS 412.30 (M+H)+.

Sources & evidence

ORD record
ord-000da230b22b44d9a5cfe74bfb0bb24a
Source dataset
uspto-grants-2009_08
Patent number
US07576098B2

Reaction notes

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