反应详情

According to the procedure for Intermediate 370.1, 3-phenyl-1-trityl-1H-1,2,4-triazole (250 mg, 0.66 mmol) and 5-ethyl-2-fluorobenzaldehyde (100 mg, 0.66 mmol) afforded 294 mg of Intermediate 384.1 as a white solid. 1H NMR (400 MHz, CD3OD) δ ppm 1.06 (t, J=7.70 Hz, 3H) 2.41 (q, J=7.58 Hz, 2H) 2.89 (d, J=9.05 Hz, 1H) 5.41 (d, J=9.29 Hz, 1H) 6.60 (dd, J=9.90, 8.44 Hz, 1H) 6.82-6.93 (m, 1H) 6.96 (dd, J=7.34, 2.20 Hz, 1H) 7.02-7.09 (m, 6H) 7.09-7.16 (m, 9H) 7.24-7.39 (m, 4H) 7.98-8.10 (m, 2H).