(5-ethyl-2-fluorophenyl)(2-methyl-5-phenyl-2H-1,2,4-triazol-3-yl)methanol → 4-((5-ethyl-2-fluorophenyl)(2-methyl-5-phenyl-2H-1,2,4-triazol-3-yl)methylamino)benzonitrile

Participants

Role	Name	HCID	Charge
Reactant	(5-ethyl-2-fluorophenyl)(2-methyl-5-phenyl-2H-1,2,4-triazol-3-yl)methanol	HCID 57803805	—
Reactant	4-((3-ethylphenyl)(2-methyl-5-phenyl-2H-1,2,4-triazol-3-yl)methylamino)-3-fluorobenzonitrile	HCID 68815332	—
Product	4-((5-ethyl-2-fluorophenyl)(2-methyl-5-phenyl-2H-1,2,4-triazol-3-yl)methylamino)benzonitrile	HCID 68815065	—

Reaction Steps

Following the procedure for Intermediate 382.1, Intermediate 385.1 (150 mg, 0.48 mmol) gave 155 mg of Intermediate 385.2 as a white solid. 1H NMR (400 MHz, CDCl3) δ ppm 0.95 (t, J=7.58 Hz, 3H) 2.35 (q, J=7.58 Hz, 2H) 3.59 (s, 3H) 5.87 (d, J=6.11 Hz, 1H) 6.35 (d, J=5.87 Hz, 1H) 6.48-6.57 (m, 2H) 6.86-6.94 (m, 1H) 6.95-7.02 (m, 1H) 7.11-7.19 (m, 1H) 7.22-7.32 (m, 5H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07576098B2
Source dataset	uspto-grants-2009_08
ORD ID	ord-852f4ef5da8a4b9e92bc8b20019de43e
Source note	uspto-grants-2009_08