反应详情

温度

60 °C

H2SO4 (0.4 mL conc, 1.6 mL H2O) was added to a solution of Intermediate 388.1 (0.25 g, 1.02 mmol) in dioxane (2 mL). The mixture was stirred at 60° C., diluted with H2O (10 mL), extracted with hexanes (2×25 mL). The organics were combined, washed with brine, dried (Na2SO4) and concentrated to yield 200 mg of Intermediate 388.2 as a clear oil. 1H NMR (400 MHz, CDCl3) δ ppm 1.47 (s, 6H) 5.01 (s, 2H) 6.98 (m, 1H) 7.32 (m, 1H) 7.37 (m, 1H).

1. extractionextracted with hexanes (2×25 mL)
2. washwashed with brine
3. dry with materialdried (Na2SO4)
4. concentrationconcentrated