Iodoethane → (3-ethoxy-5-ethyl-2-fluorophenyl)(4-phenyl-1-trityl-1H-imidazol-2-yl)methanol

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Reaction Steps

To a solution of Intermediate 448.2 (1.00 g, 1.80 mmol) in 10 mL DMF at rt, were added K2CO3 (229 mg, 2.16 mmol) and iodoethane (432 μL, 5.4 mmol). The mixture was stirred at rt for 19 h, then diluted with EtOAc. The organic phase was washed with H2O (2×), sat. Na2SO3 and brine, dried (Na2SO4), filtered through 1″ SiO2 and concentrated to afford 1.05 g of Intermediate 448.3 as a colorless solid. LCMS (2 min gradient) RT=1.92 min, 583.3 (M+H)+.

Provenance & Evidence