Dimethylformamide dimethyl acetal → 4-(Dimethylamino)-1,1-dimethoxybut-3-en-2-one

Participants

Reaction Conditions

Reaction Steps

1,1-Dimethoxypropan-2-one (57.9 g, 0.459 mol) was added to dimethyl formamide dimethyl acetal (54.6 g, 0.459 mol) and the mixture stirred and heated at 100° C. for 18 hours. The reaction mixture was allowed to cool and the volatiles removed by evaporation give the itle compound (79 g) as a red oil. NMR: (CDCl3): 2.90 (d, 3H), 3.10 (d, 3H), 3.40 (s, 6H), 4.56 (s, 1H), 5.34 (1H, d), 7.74 (d, 1H).

Provenance & Evidence