Ethanolamine → 2-[[(3-Chloro-2-fluorophenyl)methyl]thio]4-[(2-hydroxyethyl)amino]-7(8H)-pteridinone

HRID 2105148Notes

Reaction equation

HRID 2105148 reaction equation
Br[C:2]1[C:11]2[N:10]=[CH:9][C:8](=[O:12])[NH:7][C:6]=2[N:5]=[C:4]([S:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([Cl:21])[C:16]=2[F:22])[N:3]=1.[CH2:23]([CH2:25][NH2:26])[OH:24]>>[Cl:21][C:17]1[C:16]([F:22])=[C:15]([CH2:14][S:13][C:4]2[N:3]=[C:2]([NH:26][CH2:25][CH2:23][OH:24])[C:11]3[N:10]=[CH:9][C:8](=[O:12])[NH:7][C:6]=3[N:5]=2)[CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 700EthanolamineHCID 225059834-Bromo-2-[[(3-chloro-2-fluorophenyl)methyl]thio]-7(8H)-pteridinone

Product 1

HCID 225059342-[[(3-Chloro-2-fluorophenyl)methyl]thio]4-[(2-hydroxyethyl)amino]-7(8H)-pteridinone

Procedure

The titled compound (51 mg) was prepared by the method of Example 6, step (f) using the product from Example 6, step (e) (75 mg) and ethanolamine (25 μl).

Sources & evidence

ORD record
ord-e5d8f2a504484f8d90bfa08e740281f5
Source dataset
uspto-grants-2009_08
Patent number
US07579342B2

Reaction notes

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