3-Chlorobenzenemethanethiol → HCID 68817244, compound

HRID 2105156Notes

Reaction equation

HRID 2105156 reaction equation
F[C:2]1[C:7](F)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][S:10]([C:13]1[N:22]=[C:21]([NH:23][C@H:24]([CH3:27])[CH2:25][OH:26])[C:20]2[N:19]=[CH:18][C:17](=[O:28])[NH:16][C:15]=2[N:14]=1)(=O)=O.[Cl:29]C1C=C(CS)C=CC=1>>[Cl:29][C:7]1[CH:2]=[C:3]([CH2:9][S:10][C:13]2[N:22]=[C:21]([NH:23][C@H:24]([CH3:27])[CH2:25][OH:26])[C:20]3[N:19]=[CH:18][C:17](=[O:28])[NH:16][C:15]=3[N:14]=2)[CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 111056423-ChlorobenzenemethanethiolHCID 688171932-[[(2,3-Difluorophenyl)methyl]sulfonyl]-4-[[(1R)-2-hydroxy-1-methylethyl]amino]-7(8H)-pteridinone

Product 1

HCID 68817244HCID 68817244, compoundYield 35.9%

Procedure

The titled compound (66 mg) was prepared by the method of Example 13, step (c) using the product from Example 13, step (a) (0.20 g) and 3-chloro-benzenemethanethiol (92 mg).

Sources & evidence

ORD record
ord-b42118146247439dac49f50729d0bfbd
Source dataset
uspto-grants-2009_08
Patent number
US07579342B2

Reaction notes

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