Bromoform → 4-Bromo-2-[[(2,3-difluorophenyl)methyl]thio]-6(trifluoromethyl)-7(8H)-pteridinone

HRID 2105168Notes

Reaction equation

HRID 2105168 reaction equation
N[C:2]1[C:11]2[N:10]=[C:9]([C:12]([F:15])([F:14])[F:13])[C:8](=[O:16])[NH:7][C:6]=2[N:5]=[C:4]([S:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[C:20]=2[F:26])[N:3]=1.C(Br)(Br)[Br:28]>>[Br:28][C:2]1[C:11]2[N:10]=[C:9]([C:12]([F:15])([F:14])[F:13])[C:8](=[O:16])[NH:7][C:6]=2[N:5]=[C:4]([S:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[C:20]=2[F:26])[N:3]=1

Participants

3

Reactant 2

HCID 5558BromoformHCID 225060194-Amino-2-[[(2,3-difluorophenyl)methyl]thio]-6-(trifluoromethyl)-7(8H)-pteridinone

Product 1

HCID 225059584-Bromo-2-[[(2,3-difluorophenyl)methyl]thio]-6(trifluoromethyl)-7(8H)-pteridinone

Procedure

The sub-titled compound was prepared from the product of example 37, step (a) (1.5 g) and bromoform (30 ml) using the method of Example 3, step (b).

Sources & evidence

ORD record
ord-91ce241acb024537b27afe4132e2abc6
Source dataset
uspto-grants-2009_08
Patent number
US07579342B2

Reaction notes

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