Hydrazine → 1,3-Diethyl-8-[6-hydrazino-3-pyridyl]xanthine

Participants

Reaction Conditions

Reaction Steps

1,3-dipropyl-8-(6-chloro-3-pyridyl)xanthine (500 mg, 1.44 mmol) and hydrazine (4 ml) were put in a pressure tube. Ethanol (30 ml) was added. The pressure tube was flushed with argon, sealed and stirred at 100-160° C. for 10-16 h. After cooling, the resulting solid was collected and washed with methanol and ether to give compound 1 (400 mg). The product was used in the next step without further purification.

Provenance & Evidence