3-cyclopropyl-1H-pyrazol-5-amine → HCID 11431043, compound

HRID 2105191Notes

Reaction equation

HRID 2105191 reaction equation
O[C:2]1[CH:7]=[C:6]([CH2:8][O:9][CH3:10])[N:5]=[C:4]([N:11]2[CH2:15][CH2:14][CH2:13][CH:12]2[C:16]2[O:20][N:19]=[C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=3)[CH:17]=2)[N:3]=1.[NH2:27][C:28]1[CH:32]=[C:31]([CH:33]2[CH2:35][CH2:34]2)[NH:30][N:29]=1>>[CH:33]1([C:31]2[NH:30][N:29]=[C:28]([NH:27][C:2]3[CH:7]=[C:6]([CH2:8][O:9][CH3:10])[N:5]=[C:4]([N:11]4[CH2:15][CH2:14][CH2:13][CH:12]4[C:16]4[O:20][N:19]=[C:18]([C:21]5[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=5)[CH:17]=4)[N:3]=3)[CH:32]=2)[CH2:35][CH2:34]1

Participants

3

Reactant 2

HCID 27580143-cyclopropyl-1H-pyrazol-5-amineHCID 178494555HCID 178494555, compound

Product 1

HCID 11431043HCID 11431043, compound

Procedure

Starting materials: 4-hydroxy-6-methoxymethyl-2-[2-{3-(pyrid-2-yl)isoxazol-5-yl}pyrrolidin-1-yl]pyrimidine (Method 34) and 3-amino-5-cyclopropyl-1H-pyrazole (Method 7 of WO-03/048133).

Sources & evidence

ORD record
ord-566d6f0657d548e5b40a9f37ac49aa55
Source dataset
uspto-grants-2009_08
Patent number
US07579349B2

Reaction notes

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