3-cyclopropyl-1H-pyrazol-5-amine → HCID 11340636, compound

HRID 2105196Notes

Reaction equation

HRID 2105196 reaction equation
O[C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:5]=[C:4]([N:12]2[CH2:16][CH2:15][CH2:14][CH:13]2[C:17]2[O:21][N:20]=[C:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=3)[CH:18]=2)[N:3]=1.[NH2:28][C:29]1[CH:33]=[C:32]([CH:34]2[CH2:36][CH2:35]2)[NH:31][N:30]=1>>[CH:34]1([C:32]2[NH:31][N:30]=[C:29]([NH:28][C:2]3[CH:7]=[C:6]([C:8]([F:10])([F:11])[F:9])[N:5]=[C:4]([N:12]4[CH2:16][CH2:15][CH2:14][CH:13]4[C:17]4[O:21][N:20]=[C:19]([C:22]5[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=5)[CH:18]=4)[N:3]=3)[CH:33]=2)[CH2:36][CH2:35]1

Participants

3

Reactant 2

HCID 27580143-cyclopropyl-1H-pyrazol-5-amineHCID 178516144HCID 178516144, compound

Product 1

HCID 11340636HCID 11340636, compound

Procedure

Starting materials: 4-hydroxy-6-trifluoromethyl-2-[2-{3-(pyrid-2-yl)isoxazol-5-yl}pyrrolidin-1-yl]pyrimidine (Method 37) and 3-amino-5-cyclopropyl-1H-pyrazole (Method 7 of WO-03/048133).

Sources & evidence

ORD record
ord-6bdf935e00e24d2f80b128a5cfb72d54
Source dataset
uspto-grants-2009_08
Patent number
US07579349B2

Reaction notes

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